I have a soft spot for Green Ronin’s Freeport, a crime-ridden city of dirty pirates and Cthulhoid cultists. My very first D&D 3e campaign was the original Freeport trilogy and those are some fond memories. I’m actually using the Freeport stuff, hybridized with Golarions’ Riddleport, in my current Pathfinder campaign, Reavers on the Seas of Fate.
Well, word on the street (or at least on the Green Ronin forums) is that they’re working on a Pathfinder version of the Freeport setting! I’m looking forward to that. If you’ve never played in Freeport before, pick it up when it’s out and discover the joys of rapine and plunder!